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活动日期:2026.4.20-2026.5.31

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Species    
Human        

Protein Construction    
IL-18 (Tyr37-Asp193), Accession # Q14116        

Tag    
No tag

Expression System    
E. coli        

Purity    
> 95% as determined by SDS-PAGE

Predicted Molecular Mass   
18 kDa

SDS-PAGE   
17 kDa, under reducing conditions

Endotoxin    
<0.1 EU/μg of the protein by the LAL method.        

Biological Activity    
Measured by its ability to induce IFN-γ secretion by KG‑1 cells. The ED50 for this effect is <20 ng/mL.  
Formulation    
Lyophilized from a 0.22μm filtered solution in PBS with 5% Trehalose

Reconstitution    
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water  

Storage&Stability    
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.        
12 months from date of receipt, at lower than -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.

Usage    
Research use only

Background    
Interleukin-18 (IL18, also known as interferon-gamma inducing factor or IGIF) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. Its biological activity is pleiotropic and it has been shown to induce interferon-gamma production in KG-1 cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells.