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活动日期:2026.4.20-2026.5.31

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Species    
Human        

Protein Construction    
IL-1ꞵ (Ala117-Ser269), Accession # NP_000567        

Tag    
No tag

Expression System    
E. coli        

Purity    
> 95% as determined by SDS-PAGE

Predicted Molecular Mass   
17 kDa

SDS-PAGE   
17 kDa, under reducing conditions

Endotoxin    
<0.1 EU/μg of the protein by the LAL method.        

Biological Activity    
Measured by its ability to induce IFN-γ secretion by NK-92 human natural killer lymphoma cells. The ED50 for this effect is 0.2-2 ng/mL.    

Formulation    
Lyophilized from a 0.22μm filtered solution in PBS

Reconstitution    
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water  

Storage&Stability    
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.        
12 months from date of receipt, at lower than -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.

Usage    
Research use only

Background    
Interleukin-1 beta (IL-1ꞵ) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.