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活动日期:2026.4.20-2026.5.31

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Species    
Human        

Protein Construction    
IL-1α (Ser113-Ala271), Accession # Q53QF9        

Tag    
No tag

Expression System    
E. coli        

Purity    
> 95% as determined by SDS-PAGE

Predicted Molecular Mass   
18 kDa

SDS-PAGE   
17 kDa, under reducing conditions

Endotoxin    
<0.1 EU/μg of the protein by the LAL method.        

Biological Activity    
Measured by its ability to induce IFN-γ secretion by NK-92 cells. The ED50 for this effect is 0.2-2 ng/mL.              
Formulation    
Lyophilized from a 0.22μm filtered solution in PBS with 0.1% BSA  

Reconstitution    
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water  

Storage&Stability    
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.        
12 months from date of receipt, at lower than -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.

Usage    
Research use only

Background    
IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.